What layer of skin does HPV affect?
HPVs infect cells in the basal layer of squamous epithelium at multiple sites in the anogenital tract, including the cervical squamo-columnar junction, the portio surface of the cervix, the upper and lower epithelia of the vagina, multiple sites on the vulva, the perianal and intra-anal mucosa, the penile shaft, and …
What kind of epithelium is affected by HPV?
HPV will infect and replicate in a fully differentiating squamous epithelium only. The virus infectious cycle is rather complex and can explain the duration of an HPV infection. It involves both temporal and spatial separation of viral protein expression.
Where does HPV reside?
HPV lives in thin, flat cells called epithelial cells. These are found on the skin’s surface. They’re also found on the surface of the vagina, anus, vulva, cervix and head of the penis. They’re also found inside the mouth and throat.
What is the structure of the HPV virus?
Papillomaviruses are small, non-enveloped, icosahedral DNA viruses that have a diameter of 52–55 nm. The viral particles consist of a single double-stranded DNA molecule of about 8000 base-pairs (bp) that is bound to cellular histones and contained in a protein capsid composed of 72 pentameric capsomers.
What cells are infected by HPV?
HPV infects the squamous cells that line the inner surfaces of these organs. For this reason, most HPV-related cancers are a type of cancer called squamous cell carcinoma. Some cervical cancers come from HPV infection of gland cells in the cervix and are called adenocarcinomas.
How did I get HPV with only one partner?
How did I get HPV? HPV is a sexually-acquired virus. Even if you were to have sex with a single partner in your life, using condoms every time, there is an 80% chance you will acquire HPV in your lifetime. HPV can be spread by contact between genital skin, so LGBQTI people can also get the virus.
Does HPV cause health problems?
Does HPV cause health problems? In most cases (9 out of 10), HPV goes away on its own within two years without health problems. But when HPV does not go away, it can cause health problems like genital warts and cancer. Genital warts usually appear as a small bump or group of bumps in the genital area.