What is the 5 HTT gene responsible for?

What is the 5 HTT gene responsible for?

The serotonin transporter (5-HTT, SERT, SLC6A4) is responsible for recycling serotonin from the synaptic cleft to the presynaptic neuron, terminating its effects and enabling its reuse (Murphy et al., 2004). A length polymorphism in its gene promoter (5-HTTLPR) results in differing levels of transporter expression.

What does the serotonin transporter gene do?

Function. The serotonin transporter removes serotonin from the synaptic cleft back into the synaptic boutons. Thus, it terminates the effects of serotonin and simultaneously enables its reuse by the presynaptic neuron.

Which version of the serotonin transporter gene is associated with depression?

The gene most commonly associated with depression is the serotonin transporter gene SLC6A4 (Bleys et al., 2018). Serotonin is a neurotransmitter affecting multiple physiological processes and cognitive brain functions, among them mood and emotions, which is why it has been linked to mood disorders such as depression.

What appears to be the role of the 5-HTT gene in relationship to depression?

The 5-HTT gene has been associated with both depression and autism. The serotonin transporter protein (5-HTT/SLC6A4) transports the neurotransmitter serotonin from synapses to presynaptic neurons. It seems to be an important component in the physiological response to cocaine and amphetamines.

Why is SERT important?

SERT has garnered significant clinical attention partly because it is the target of multiple psychoactive agents, including the antidepressant paroxetine (Paxil), the most potent selective serotonin reuptake inhibitor known. However, the binding site and orientation of paroxetine in SERT remain controversial.

How do antidepressants work?

Antidepressants work by balancing chemicals in your brain called neurotransmitters that affect mood and emotions. These depression medicines can help improve your mood, help you sleep better, and increase your appetite and concentration.

What occurs when children passively inherit the genes and the environments their family provides?

Passive genotype-environment correlation occurs when children passively inherit the genes and the environments their family provides. Certain behavioral characteristics, such as being athletically inclined, may run in families.

Where is the 5-HTT gene located?

Re-uptake by the 5-HT transporter (5-HTT or SLC6A4) is a major mechanism that removes 5-HT from the synaptic cleft after release. The human gene is located on chromosome 17q11. 2 and consists of 15 exons.

Can 5-HTP cause diarrhea?

The most common side effects include heartburn, stomach pain, nausea, vomiting, diarrhea, drowsiness, sexual problems, and muscle problems. Large doses of 5-HTP, such as 6-10 grams daily, are possibly unsafe. These doses have been linked to severe stomach problems and muscle spasms.

What is the function of the serotonin transporter 5 httlpr?

The function of the serotonin transporter is degraded among carriers of the short 5-HTTLPR allele (12, 13). As a result, carriers of the short 5-HTTLPR allele have increased levels of extracellular serotonin and increased serotonin signaling compared with those who have two long alleles.

What does 5-HTTLPR stand for?

Mean attentional bias scores (in milliseconds) across allele groups for the serotonin transporter promoter region polymorphism (5-HTTLPR). Error bars reflect standard error of the mean.

How does the 5-HTTLPR allele affect extracellular serotonin?

As a result, carriers of the short 5-HTTLPR allele have increased levels of extracellular serotonin and increased serotonin signaling compared with those who have two long alleles.

Do polymorphisms in the 5-HTT and BDNF genes predict post-stroke depression?

Polymorphisms in the 5-HTT and BDNF genes are shown to affect their function at the molecular and serum level. Prior work has tried to correlate the polymorphisms with post-stroke depression (PSD), the results nevertheless remain indefinitive. A plausible reason accounting for the uncertainty relates to the small sample of each published trial.