What is role of hepatocyte growth factor?
Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met.
Is hepatocyte growth factor safe?
Increase in ankle pressure index more than 0.1 was observed in 5 of 5 patients. The long diameter of 8 of 11 ischemic ulcers in 4 patients was reduced >25%. Intramuscular injection of naked HGF plasmid is safe, feasible, and can achieve successful improvement of ischemic limbs.
What does HGF mean?
hepatocyte growth factor
Hepatocyte growth factor
|Aliases||HGF, DFNB39, F-TCF, HGFB, HPTA, SF, hepatocyte growth factor|
|External IDs||OMIM: 142409 MGI: 96079 HomoloGene: 503 GeneCards: HGF|
|showGene location (Human)|
|showRNA expression pattern|
Is hepatocyte growth factor a protein?
MET Ligand HGF/SF was isolated concurrently as a liver mitogen (hepatocyte growth factor) and as a motility factor for epithelial cells (scatter factor). HGF/SF is a protein of 728 amino acids that differs from other polypeptide growth factors and is closely related to the proenzyme plasminogen.
Do hepatocytes produce HGF?
It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor, c-Met.
What is hepatocyte?
Liver cells, or hepatocytes, have direct access to the liver’s blood supply through small capillaries called sinusoids. Hepatocytes carry out many metabolic functions, including the production of bile.
Is HGF a hormone?
Hepatocyte growth factor as cardiovascular hormone: role of HGF in the pathogenesis of cardiovascular disease.
Where is hepatocyte growth factor produced?
HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor, c-Met.
What are primary hepatocytes?
Hepatocytes directly isolated from liver tissue are called primary hepatocytes. Many other cell culture models have been used to simulate the liver environment for research and development. Some of these alternative hepatocyte models include tumor cell lines such as Huh-7 and HepG2 cells.
What is the function of the hepatocytes?
Hepatocytes, the major parenchymal cells in the liver, play pivotal roles in metabolism, detoxification, and protein synthesis. Hepatocytes also activate innate immunity against invading microorganisms by secreting innate immunity proteins.
What are hematopoietic growth factors?
Hematopoietic growth factors are glycoproteins that regulate the proliferation, differentiation, and maturation of progenitor cells, as well as the function of the mature cells. Blood cells have a limited life span, so the ability to produce such cells is an important function of the body for continual renewal.
What is function of hepatocyte?
The hepatocytes carry out many cellular functions that involve processes of synthesis, degradation and storage of numerous substances, in addition to enabling the exchange of metabolites from and to the blood.
What factors affect GDP growth?
Population growth (Immigration)
What are growth factors and blood platelets?
These specific components in blood include platelet derived growth factor (PDGF) and transforming growth factor beta (TGFß), both of which are contained within the alpha granules of platelets, and fibronectin and vitronetin, which are cell adhesion molecules found in plasma, and fibrin itself.